New Orleans, 1900. The virtuoso cornet player Charles "Buddy Bolden invents jazz, but after a life consumed by tragedy, the groundbreaking sound of his horn vanishes with him. Rumors persist, though, that Bolden recorded a phonograph cylinder, and over the course of a century it evolves into the elusive holy grail of jazz. Florida, the present day. Dr. Ruby Cardillo's life is falling apart. Her husband, a prominent cardiologist, has left her for a twenty-six-year-old. Her daughter, Devon, a once promising jazz pianist, has recently finished an enforced stint picking up trash along the interstate after a drug conviction. Ruby's estranged mother has just died, but not before conjuring up ghosts that Ruby thought she had put behind her long ago. After a long career as a well-respected anesthesiologist, Ruby suddenly jumps the tracks, forgetting to sleep and eat, indulging her every whim, wearing only purple, consuming only bottles of 1988 Chateau Latour. Then Ruby enlists Devon to accompany her on an impulsive road trip to New York, and both mother and daughter get more than they bargained for, discovering that their own shrouded family history is connected to the tantalizing search for Buddy Bolden's long-lost cylinder.
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